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P0300 Chevrolet AutoCodes Q&A . Chevrolet p0300 causes multiple misfires can be caused by many reasons from a faulty ignition system, fuel system, or internal engine failure. Remove corrosion and apply dielectric grease home I have a PO300 code on my 2004 Silverado 6.0L engine. Misfires on cyl 3,5,6,and 8. 2000 later from www.justanswer.com Chevrolet p0300 causes multiple misfires can be caused by many reasons from a faulty ignition system, fuel system, or internal engine failure. A misfire from one or more. Today a customer dropped off his 2005 chevy silverado 5.3l pickup complaining of a rough running condition, black smoke coming from the tailpipe and a check.