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Compounds and Mixtures Lesson Plans and Lesson Ideas BrainPOP Educators . Mixtures are created through chemical reactions. Compounds are two or more atoms. Atoms BrainPOP Compounds and mixtures, Atom, How to introduce yourself from www.pinterest.com The reaction that makes a ________ is relatively hard to undo. That’s the big difference between mixtures and compounds—with a compound, a chemical change takes place, and with a mixture, a physical change takes place. Whose properties are different from those of the original elements.